Proton-Pumping-ATPase-Targeted Antifungal Activity of a Novel Conjugated Styryl Ketone

NC1175 (3-[3-(4-chlorophenyl)-2-propenoyl]-4-[2-(4-chlorophenyl)vinylene]-1-ethyl-4-piperidinol hydrochloride) is a novel thiol-blocking conjugated styryl ketone that exhibits activity against a wide spectrum of pathogenic fungi. Incubation of NC1175 with various concentrations of cysteine and gluta...

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Bibliographic Details
Main Authors: Manavathu, Elias K., Dimmock, Jonathan R., Vashishtha, Sarvesh C., Chandrasekar, Pranatharthi H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89593/
https://ncbi.nlm.nih.gov/pubmed/10582888
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