Pharmacokinetics of [(14)C]Abacavir, a Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitor, Administered in a Single Oral Dose to HIV-1-Infected Adults: a Mass Balance Study

Abacavir (1592U89) {(−)-(1S, 4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol} is a 2′-deoxyguanosine analogue with potent activity against human immunodeficiency virus (HIV) type 1. To determine the metabolic profile, routes of elimination, and total recovery of abacavir...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	McDowell, James A., Chittick, Gregory E., Ravitch, Joshua R., Polk, Ronald E., Kerkering, Thomas M., Stein, Daniel S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10582871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.12.2855
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