Overexpression of Erg11p by the Regulatable GAL1 Promoter Confers Fluconazole Resistance in Saccharomyces cerevisiae

The contribution of the dosage of target enzyme P-450 14α-demethylase (14αDM) to fluconazole resistance in both Candida albicans and Saccharomyces cerevisiae remains unclear. Here, we show that overexpression of Saccharomyces P-450 14αDM in S. cerevisiae, under the control of the regulatable promote...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Kontoyiannis, Dimitrios P., Sagar, Namita, Hirschi, Kendal D.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1999
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10543768/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.11.2798
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