Overexpression of Sbe2p, a Golgi Protein, Results in Resistance to Caspofungin in Saccharomyces cerevisiae

Caspofungin inhibits the synthesis of 1, 3-β-d-glucan, an essential cell wall target in fungi. Genetic studies in the model yeast Saccharomyces cerevisiae have shown that mutations in FKS1 and FKS2 genes result in caspofungin resistance. However, direct demonstration of the role of gene overexpressi...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Osherov, Nir, May, Gregory S., Albert, Nathaniel D., Kontoyiannis, D. P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127366/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12121919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.8.2462-2469.2002
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