In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z-Methylenecyclopropane Nucleoside Analogues

Two methylenecyclopropane nucleoside analogues with a phenylphosphoralaninate moiety, QYL-685 and QYL-609, exert potent and specific activities against human immunodeficiency virus type 1 strain LAI (HIV-1(LAI)) and HIV-2 in vitro. In this study, we induced HIV-1 variants resistant to QYL-685 by exp...

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Détails bibliographiques
Auteurs principaux: Yoshimura, Kazuhisa, Feldman, Ron, Kodama, Eiichi, Kavlick, Mark F., Qiu, Yao-Ling, Zemlicka, Jiri, Mitsuya, Hiroaki
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC89504/
https://ncbi.nlm.nih.gov/pubmed/10508028
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