In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z-Methylenecyclopropane Nucleoside Analogues

Two methylenecyclopropane nucleoside analogues with a phenylphosphoralaninate moiety, QYL-685 and QYL-609, exert potent and specific activities against human immunodeficiency virus type 1 strain LAI (HIV-1(LAI)) and HIV-2 in vitro. In this study, we induced HIV-1 variants resistant to QYL-685 by exp...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Yoshimura, Kazuhisa, Feldman, Ron, Kodama, Eiichi, Kavlick, Mark F., Qiu, Yao-Ling, Zemlicka, Jiri, Mitsuya, Hiroaki
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89504/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2479
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