Relationship between Pyrazinamide Resistance, Loss of Pyrazinamidase Activity, and Mutations in the pncA Locus in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis

Sixty-two Mycobacterium tuberculosis isolates were tested for pyrazinamidase activity, and their pyrazinamide susceptibility was determined by the radiometric method. Sequencing of pncA genes in the 23 resistant strains revealed mutations in 16 pyrazinamidase-negative strains, 11 of which had not be...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Mestdagh, M., Fonteyne, P. A., Realini, L., Rossau, R., Jannes, G., Mijs, W., De Smet, K. A. L., Portaels, F., Van den Eeckhout, E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.9.2317
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