Relationship between Pyrazinamide Resistance, Loss of Pyrazinamidase Activity, and Mutations in the pncA Locus in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis

Sixty-two Mycobacterium tuberculosis isolates were tested for pyrazinamidase activity, and their pyrazinamide susceptibility was determined by the radiometric method. Sequencing of pncA genes in the 23 resistant strains revealed mutations in 16 pyrazinamidase-negative strains, 11 of which had not be...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Antimicrob Agents Chemother
المؤلفون الرئيسيون:	Mestdagh, M., Fonteyne, P. A., Realini, L., Rossau, R., Jannes, G., Mijs, W., De Smet, K. A. L., Portaels, F., Van den Eeckhout, E.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	American Society for Microbiology (ASM) 1999
الموضوعات:	Mechanisms of Resistance
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.9.2317
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!