Identification of Functional Amino Acids in the Macrolide 2′-Phosphotransferase II

Macrolide 2′-phosphotransferase [MPH(2′)] transfers the γ phosphate of ATP to the 2′-OH group of macrolide antibiotics. The role of aspartic acids in the putative ATP-binding site of MPH(2′)II was investigated through the substitution of alanine for aspartate by site-directed mutagenesis. D200A, D20...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Taniguchi, Kazuo, Nakamura, Akio, Tsurubuchi, Kazue, Ishii, Aki, O’Hara, Koji, Sawai, Tetsuo
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1999
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.2063
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