Identification of Functional Amino Acids in the Macrolide 2′-Phosphotransferase II

Macrolide 2′-phosphotransferase [MPH(2′)] transfers the γ phosphate of ATP to the 2′-OH group of macrolide antibiotics. The role of aspartic acids in the putative ATP-binding site of MPH(2′)II was investigated through the substitution of alanine for aspartate by site-directed mutagenesis. D200A, D20...

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Main Authors: Taniguchi, Kazuo, Nakamura, Akio, Tsurubuchi, Kazue, Ishii, Aki, O’Hara, Koji, Sawai, Tetsuo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89416/
https://ncbi.nlm.nih.gov/pubmed/10428938
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