Identification of Functional Amino Acids in the Macrolide 2′-Phosphotransferase II
Macrolide 2′-phosphotransferase [MPH(2′)] transfers the γ phosphate of ATP to the 2′-OH group of macrolide antibiotics. The role of aspartic acids in the putative ATP-binding site of MPH(2′)II was investigated through the substitution of alanine for aspartate by site-directed mutagenesis. D200A, D20...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.2063 |
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