Evaluation of Low-Dose, Extended-Interval Clindamycin Regimens against Staphylococcus aureus and Streptococcus pneumoniae Using a Dynamic In Vitro Model of Infection

We have previously described the activity of low-dose clindamycin in extended-interval dosing regimens by determination of bactericidal titer in serum. In this study, we used a one-compartment in vitro dynamic infection model to compare the pharmacodynamics of clindamycin in three intravenous-dosing...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Lewis, Russell E., Klepser, Michael E., Ernst, Erika J., Lund, Brian C., Biedenbach, Douglas J., Jones, Ronald N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89405/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428927/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.2005
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