Activities of Trovafloxacin Compared with Those of Other Fluoroquinolones against Purified Topoisomerases and gyrA and grlA Mutants of Staphylococcus aureus

Frequencies of mutation to resistance with trovafloxacin and four other quinolones were determined with quinolone-susceptible Staphylococcus aureus RN4220 by a direct plating method. First-step mutants were selected less frequently with trovafloxacin (1.1 × 10(−10) at 2 to 4× the MIC) than with levo...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Gootz, Thomas D., Zaniewski, Richard P., Haskell, Suzanne L., Kaczmarek, Frank S., Maurice, Alison E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1845
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