In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy tha...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Akova, Murat, Gür, Deniz, Livermore, David M., Kocagöz, Tanil, Akalin, H. Erdal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Susceptibility
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89265/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1298
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