N-Acylated and d Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity

N-acylated or d enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times...

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Main Authors: Wakabayashi, Hiroyuki, Matsumoto, Hiroshi, Hashimoto, Koichi, Teraguchi, Susumu, Takase, Mitsunori, Hayasawa, Hirotoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89256/
https://ncbi.nlm.nih.gov/pubmed/10223949
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