The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity

We report here that bloodstream forms of the African trypanosome, Trypanosoma brucei, are sensitive to the anti-influenza virus drug rimantadine (50% inhibitory concentration of 1.26 μg ml(−1) at pH 7.4). The activity is pH dependent and is consistent with a mechanism involving inhibition of the abi...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kelly, John M., Miles, Michael A., Skinner, Anita C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10103219/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.4.985
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