In Vivo Activities of Peptidic Prodrugs of Novel Aminomethyl Tetrahydrofuranyl-1β-Methylcarbapenems

A series of novel aminomethyl tetrahydrofuranyl (THF)-1β-methylcarbapenems which have excellent broad-spectrum antibacterial activities exhibit modest efficacies against acute lethal infections (3.8 mg/kg of body weight against Escherichia coli and 0.9 mg/kg against Staphylococcus aureus) in mice wh...

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Détails bibliographiques
Auteurs principaux: Weiss, William J., Mikels, Susan M., Petersen, Peter J., Jacobus, Nilda V., Bitha, Panayota, Lin, Yang-I., Testa, Raymond T.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC89144/
https://ncbi.nlm.nih.gov/pubmed/10049251
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