Genes Specific for the Biosynthesis of Clavam Metabolites Antipodal to Clavulanic Acid Are Clustered with the Gene for Clavaminate Synthase 1 in Streptomyces clavuligerus

Portions of the Streptomyces clavuligerus chromosome flanking cas1, which encodes the clavaminate synthase 1 isoenzyme (CAS1), have been cloned and sequenced. Mutants of S. clavuligerus disrupted in cvm1, the open reading frame located immediately upstream of cas1, were constructed by a gene replace...

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Hlavní autoři: Mosher, Roy H., Paradkar, Ashish S., Anders, Cecilia, Barton, Barry, Jensen, Susan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Chemistry; Biosynthesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC89136/
https://ncbi.nlm.nih.gov/pubmed/10223939
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