Genes Specific for the Biosynthesis of Clavam Metabolites Antipodal to Clavulanic Acid Are Clustered with the Gene for Clavaminate Synthase 1 in Streptomyces clavuligerus
Portions of the Streptomyces clavuligerus chromosome flanking cas1, which encodes the clavaminate synthase 1 isoenzyme (CAS1), have been cloned and sequenced. Mutants of S. clavuligerus disrupted in cvm1, the open reading frame located immediately upstream of cas1, were constructed by a gene replace...
Saved in:
| Published in: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
1999
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1215 |
| Tags: |
No Tags, Be the first to tag this record!
|