In Vitro Activities of the Potent, Broad-Spectrum Carbapenem MK-0826 (L-749,345) against Broad-Spectrum β-Lactamase-and Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae and Escherichia coli Clinical Isolates

An important mechanism of bacterial resistance to β-lactam antibiotics is inactivation by β-lactam-hydrolyzing enzymes (β-lactamases). The evolution of the extended-spectrum β-lactamases (ESBLs) is associated with extensive use of β-lactam antibiotics, particularly cephalosporins, and is a serious t...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Kohler, Joyce, Dorso, Karen L., Young, Katherine, Hammond, Gail G., Rosen, Hugh, Kropp, Helmut, Silver, Lynn L.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Assuntos:	Susceptibility
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223931/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1170
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