Carbapenem Activities against Pseudomonas aeruginosa: Respective Contributions of OprD and Efflux Systems

While meropenem MICs were strongly influenced by the presence or absence of the MexAB-OprM efflux pump in both OprD-proficient and -deficient strain backgrounds, MICs of imipenem and of ER-35786 remained unchanged, demonstrating that meropenem is a substrate of MexAB-OprM but not imipenem and ER-357...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Köhler, Thilo, Michea-Hamzehpour, Mehri, Epp, Simone F., Pechere, Jean-Claude
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89097/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.424
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