In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

The 50% inhibitory concentration (IC(50)s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No c...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Pradines, Bruno, Tall, Adama, Fusai, Thierry, Spiegel, Andre, Hienne, Remi, Rogier, Christophe, Trape, Jean Francois, Le Bras, Jacques, Parzy, Daniel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Susceptibility
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.418
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