In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

The 50% inhibitory concentration (IC(50)s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). N...

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Hauptverfasser: Pradines, Bruno, Tall, Adama, Fusai, Thierry, Spiegel, Andre, Hienne, Remi, Rogier, Christophe, Trape, Jean Francois, Le Bras, Jacques, Parzy, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89095/
https://ncbi.nlm.nih.gov/pubmed/9925550
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