Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani

The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Petit, C., Yardley, V., Gaboriau, F., Bolard, J., Croft, S. L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Susceptibility
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925541/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.390
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