In Vivo Emergence of Multidrug-Resistant Mutants of Pseudomonas aeruginosa Overexpressing the Active Efflux System MexA-MexB-OprM

During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal β-lactam antibiotics were isolated from hospitalized patients. In vivo emergence of β-lactam resistance was associated with the overexpression of AmpC β-lactam...

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Bibliografiske detaljer
Main Authors: Ziha-Zarifi, Isabelle, Llanes, Catherine, Köhler, Thilo, Pechere, Jean-Claude, Plesiat, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89065/
https://ncbi.nlm.nih.gov/pubmed/9925520
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