In Vivo Emergence of Multidrug-Resistant Mutants of Pseudomonas aeruginosa Overexpressing the Active Efflux System MexA-MexB-OprM

During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal β-lactam antibiotics were isolated from hospitalized patients. In vivo emergence of β-lactam resistance was associated with the overexpression of AmpC β-lactam...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Ziha-Zarifi, Isabelle, Llanes, Catherine, Köhler, Thilo, Pechere, Jean-Claude, Plesiat, Patrick
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925520/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.287
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