The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1

N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide (UC781) is an exceptionally potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. We found that a 1:1 molar combination of UC781 and 3′-azido-3′-deoxythymidine (AZT) showed high...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Borkow, Gadi, Arion, Dominique, Wainberg, Mark A., Parniak, Michael A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Assuntos:	Antiviral Agents
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.259
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