Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10(−5) and 2.7 × 10(−4) M,...
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| Publicado en: | Antimicrob Agents Chemother |
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| Autor principal: | |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9869588/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.1.175 |
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