The Susceptibility of Mycobacterium tuberculosis to Isoniazid and the Arg→Leu Mutation at Codon 463 of katG Are Not Associated

A mutation (CCG→CTG [Arg→Leu]) in codon 463 of katG (catalase peroxidase) of Mycobacterium tuberculosis has been found in isoniazid (INH)-resistant strains. A PCR restriction endonuclease analysis to detect this mutation was applied to 395 M. tuberculosis isolates from patients in The Netherlands. T...

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Autori principali: van Doorn, H. R., Kuijper, E. J., van der Ende, A., Welten, A. G. A., van Soolingen, D., de Haas, P. E. W., Dankert, J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Mycobacteriology and Aerobic Actinomycetes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC87976/
https://ncbi.nlm.nih.gov/pubmed/11283093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.39.4.1591-1594.2001
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