Disruption of γ-Glutamyl Leukotrienase Results in Disruption of Leukotriene D(4) Synthesis In Vivo and Attenuation of the Acute Inflammatory Response

To study the function of γ-glutamyl leukotrienase (GGL), a newly identified member of the γ-glutamyl transpeptidase (GGT) family, we generated null mutations in GGL (GGL(tm1)) and in both GGL and GGT (GGL(tm1)-GGT(tm1)) by a serial targeting strategy using embryonic stem cells. Mice homozygous for G...

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Détails bibliographiques
Auteurs principaux: Shi, Zheng-Zheng, Han, Bing, Habib, Geetha M., Matzuk, Martin M., Lieberman, Michael W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87261/
https://ncbi.nlm.nih.gov/pubmed/11463821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5389-5395.2001
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