Hic-5-Reduced Cell Spreading on Fibronectin: Competitive Effects between Paxillin and Hic-5 through Interaction with Focal Adhesion Kinase

Hic-5 is a paxillin homologue that is localized to focal adhesion complexes. Hic-5 and paxillin share structural homology and interacting factors such as focal adhesion kinase (FAK), Pyk2/CAKβ/RAFTK, and PTP-PEST. Here, we showed that Hic-5 inhibits integrin-mediated cell spreading on fibronectin in...

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Bibliographische Detailangaben
Hauptverfasser: Nishiya, Naoyuki, Tachibana, Kouichi, Shibanuma, Motoko, Mashimo, Jun-Ichi, Nose, Kiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87257/
https://ncbi.nlm.nih.gov/pubmed/11463817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5332-5345.2001
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