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Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

Translation initiation factor 2 (eIF2) is a heterotrimeric protein that transfers methionyl-initiator tRNA(Met) to the small ribosomal subunit in a ternary complex with GTP. The eIF2 phosphorylated on serine 51 of its α subunit [eIF2(αP)] acts as competitive inhibitor of its guanine nucleotide excha...

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Udgivet i:Mol Cell Biol
Principais autores: Krishnamoorthy, Thanuja, Pavitt, Graham D., Zhang, Fan, Dever, Thomas E., Hinnebusch, Alan G.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87228/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438658/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.15.5018-5030.2001
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