Mechanism of Prion Loss after Hsp104 Inactivation in Yeast

In vivo propagation of [PSI(+)], an aggregation-prone prion isoform of the yeast release factor Sup35 (eRF3), has previously been shown to require intermediate levels of the chaperone protein Hsp104. Here we perform a detailed study on the mechanism of prion loss after Hsp104 inactivation. Complete...

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Main Authors: Wegrzyn, Renee D., Bapat, Kavita, Newnam, Gary P., Zink, Amy D., Chernoff, Yury O.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC87136/
https://ncbi.nlm.nih.gov/pubmed/11416143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.14.4656-4669.2001
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