Requirement of CDC45 for Postimplantation Mouse Development

CDC45 is required for the initiation of DNA replication in Saccharomyces cerevisiae and functions as a DNA polymerase α loading factor in Xenopus, but its role in mammalian DNA replication is unknown. To investigate the genetic and physiological functions of CDC45, we used a gene targeting strategy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yoshida, Kenichi, Kuo, Frank, George, Elizabeth L., Sharpe, Arlene H., Dutta, Anindya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87121/
https://ncbi.nlm.nih.gov/pubmed/11416137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.14.4598-4603.2001
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