p38 Mitogen-Activated Protein Kinase-Dependent Activation of Protein Phosphatases 1 and 2A Inhibits MEK1 and MEK2 Activity and Collagenase 1 (MMP-1) Gene Expression

Degradation of collagenous extracellular matrix by collagenase 1 (also known as matrix metalloproteinase 1 [MMP-1]) plays a role in the pathogenesis of various destructive disorders, such as rheumatoid arthritis, chronic ulcers, and tumor invasion and metastasis. Here, we have investigated the role...

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Bibliografiske detaljer
Main Authors: Westermarck, Jukka, Li, Song-Ping, Kallunki, Tuula, Han, Jiahuai, Kähäri, Veli-Matti
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86870/
https://ncbi.nlm.nih.gov/pubmed/11259586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.7.2373-2383.2001
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