Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

The transforming growth factor-β (TGF-β) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor progression, TGF-β promotes malignancy. TGF-β activates phosphorylation of Smad2 and -3 effectors. Smad2 and -3 are known to have different funct...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Heikkinen, Pekka T., Nummela, Marika, Leivonen, Suvi-Katri, Westermarck, Jukka, Hill, Caroline S., Kähäri, Veli-Matti, Jaakkola, Panu M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823515/
https://ncbi.nlm.nih.gov/pubmed/19951945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042978
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados