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Hypoxia-activated Smad3-specific Dephosphorylation by PP2A
The transforming growth factor-β (TGF-β) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor progression, TGF-β promotes malignancy. TGF-β activates phosphorylation of Smad2 and -3 effectors. Smad2 and -3 are known to have different funct...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823515/ https://ncbi.nlm.nih.gov/pubmed/19951945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042978 |
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