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Mitochondrial DNA Instability and Peri-Implantation Lethality Associated with Targeted Disruption of Nuclear Respiratory Factor 1 in Mice

In vitro studies have implicated nuclear respiratory factor 1 (NRF-1) in the transcriptional expression of nuclear genes required for mitochondrial respiratory function, as well as for other fundamental cellular activities. We investigated here the in vivo function of NRF-1 in mammals by disrupting...

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Bibliografske podrobnosti
Main Authors: Huo, Lei, Scarpulla, Richard C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC86640/
https://ncbi.nlm.nih.gov/pubmed/11134350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.644-654.2001
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