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Lipopolysaccharide-Induced Activation of β2-Integrin Function in Macrophages Requires Irak Kinase Activity, p38 Mitogen- Activated Protein Kinase, and the Rap1 GTPase
Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, is a potent activator of macrophages. Besides inducing many transcriptional pathways, LPS also elicits rapid morphological changes such as cell spreading. Here we have investigated the signaling pathway that contr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86592/ https://ncbi.nlm.nih.gov/pubmed/11134332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.438-448.2001 |
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