The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1

Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially large number of distinct E3 ubiquitin ligases. We report here that the highly conserved C-terminal sequence in CUL1 is dually required, both for nuclear localization and for modificati...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Furukawa, Manabu, Zhang, Yanping, McCarville, Joseph, Ohta, Tomohiko, Xiong, Yue
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86428/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11027288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.21.8185-8197.2000
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