Down-Regulation of Cyclin D1 Expression by Prostaglandin A(2) Is Mediated by Enhanced Cyclin D1 mRNA Turnover

Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines. Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 e...

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Autors principals: Lin, Shankung, Wang, Wengong, Wilson, Gerald M., Yang, Xiaoling, Brewer, Gary, Holbrook, Nikki J., Gorospe, Myriam
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86401/
https://ncbi.nlm.nih.gov/pubmed/11027261
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