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Down-Regulation of Cyclin D1 Expression by Prostaglandin A(2) Is Mediated by Enhanced Cyclin D1 mRNA Turnover

Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines. Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 e...

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Publicado no:Mol Cell Biol
Principais autores: Lin, Shankung, Wang, Wengong, Wilson, Gerald M., Yang, Xiaoling, Brewer, Gary, Holbrook, Nikki J., Gorospe, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2000
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86401/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11027261/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.21.7903-7913.2000
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