Loss of p19(ARF) Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation

At least three domains of simian virus 40 large T antigen (TAg) participate in cellular transformation. The LXCXE motif of TAg binds to all members of the retinoblastoma protein (pRB) family of tumor suppressors. The N-terminal 70 residues of TAg have significant homology to the J domain of Hsp40/Dn...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Chao, Herta H. A., Buchmann, Ann M., DeCaprio, James A.
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 2000
Subjects:	Cell Growth and Development
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86324/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11003658/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.20.7624-7633.2000
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