Loss of p19(ARF) Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation

At least three domains of simian virus 40 large T antigen (TAg) participate in cellular transformation. The LXCXE motif of TAg binds to all members of the retinoblastoma protein (pRB) family of tumor suppressors. The N-terminal 70 residues of TAg have significant homology to the J domain of Hsp40/Dn...

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Bibliografske podrobnosti
Main Authors: Chao, Herta H. A., Buchmann, Ann M., DeCaprio, James A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC86324/
https://ncbi.nlm.nih.gov/pubmed/11003658
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