Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression

Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as many other cell types. Interaction of PDGF BB with the PDGF β receptor (PDGF-βR) activates numerous signaling pathways and leads to a decrease in receptor expression on the cell surface. PDGF-βR downregulation...

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Bibliographic Details
Main Authors: Oster, Sara K., Marhin, Wilson W., Asker, Charlotte, Facchini, Linda M., Dion, Patrick A., Funa, Keiko, Post, Martin, Sedivy, John M., Penn, Linda Z.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86202/
https://ncbi.nlm.nih.gov/pubmed/10958674
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