Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts

Irreversible G(1) arrest in senescent human fibroblasts is mediated by two inhibitors of cyclin-dependent kinases (Cdks), p21(Cip1/SDI1/WAF1) and p16(Ink4A). To determine the physiological and molecular events that specifically require p21, we studied senescence in human diploid fibroblasts expressi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Dulić, Vjekoslav, Beney, Georges-Edouard, Frebourg, Guillaume, Drullinger, Linda F., Stein, Gretchen H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10958672/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.18.6741-6754.2000
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