Physical Association of Eukaryotic Initiation Factor 4G (eIF4G) with eIF4A Strongly Enhances Binding of eIF4G to the Internal Ribosomal Entry Site of Encephalomyocarditis Virus and Is Required for Internal Initiation of Translation

Mammalian eukaryotic initiation factor 4GI (eIF4GI) may be divided into three similarly sized regions. The central region (amino acids [aa] 613 to 1090) binds eIF3, eIF4A, and the encephalomyocarditis virus (EMCV) internal ribosomal entry site (IRES) and mediates initiation on this RNA. We identifie...

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Autores principales: Lomakin, Ivan B., Hellen, Christopher U. T., Pestova, Tatyana V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC86078/
https://ncbi.nlm.nih.gov/pubmed/10913184
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