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Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

The tumor suppressor protein p53 is frequently inactivated in tumors. It functions as a transcriptional activator as well as a repressor for a number of viral and cellular promoters transcribed by RNA polymerase II (Pol II) and by RNA Pol III. Moreover, it appears that p53 also suppresses RNA Pol I...

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Bibliographic Details
Main Authors: Zhai, Weiguo, Comai, Lucio
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86070/
https://ncbi.nlm.nih.gov/pubmed/10913176
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