Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies

Lignende værker

• The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2
  af: Aidinis, Vassilis, et al.
  Udgivet: (1999)
• N-terminal RAG1 frameshift mutations in Omenn's syndrome: Internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains
  af: Santagata, Sandro, et al.
  Udgivet: (2000)
• RAG gene defects at the verge of immunodeficiency and immune dysregulation
  af: Villa, Anna, et al.
  Udgivet: (2019)
• Roles of the “Dispensable” Portions of RAG-1 and RAG-2 in V(D)J Recombination
  af: Steen, S. B., et al.
  Udgivet: (1999)
• A RAG1 and RAG2 Tetramer Complex Is Active in Cleavage in V(D)J Recombination
  af: Bailin, Tu, et al.
  Udgivet: (1999)