Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the role of PTP-1B in vivo, we generated homozygotic PTP-1B-null mice by targeted gene disru...

Full description

Saved in:
Bibliographic Details
Main Authors: Klaman, Lori D., Boss, Olivier, Peroni, Odile D., Kim, Jason K., Martino, Jennifer L., Zabolotny, Janice M., Moghal, Nadeem, Lubkin, Margaret, Kim, Young-Bum, Sharpe, Arlene H., Stricker-Krongrad, Alain, Shulman, Gerald I., Neel, Benjamin G., Kahn, Barbara B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC85999/
https://ncbi.nlm.nih.gov/pubmed/10891488
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items