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The C Terminus of the Saccharomyces cerevisiae α-Factor Receptor Contributes to the Formation of Preactivation Complexes with Its Cognate G Protein

Binding of the α-factor pheromone to its G-protein-coupled receptor (encoded by STE2) activates the mating pathway in MATa yeast cells. To investigate whether specific interactions between the receptor and the G protein occur prior to ligand binding, we analyzed dominant-negative mutant receptors th...

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Главные авторы: Dosil, Mercedes, Schandel, Kimberly A., Gupta, Ekta, Jenness, Duane D., Konopka, James B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC85981/
https://ncbi.nlm.nih.gov/pubmed/10866688
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