Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

Calpains are a family of Ca(2+)-dependent intracellular cysteine proteases, including the ubiquitously expressed μ- and m-calpains. Both μ- and m-calpains are heterodimers, consisting of a distinct large 80-kDa catalytic subunit, encoded by the genes Capn1 and Capn2, and a common small 28-kDa regula...

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Main Authors: Arthur, J. Simon C., Elce, John S., Hegadorn, Carol, Williams, Karen, Greer, Peter A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2000
נושאים:
Mammalian Genetic Models with Minimal or Complex Phenotypes
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC85815/
https://ncbi.nlm.nih.gov/pubmed/10825211
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