Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

Calpains are a family of Ca(2+)-dependent intracellular cysteine proteases, including the ubiquitously expressed μ- and m-calpains. Both μ- and m-calpains are heterodimers, consisting of a distinct large 80-kDa catalytic subunit, encoded by the genes Capn1 and Capn2, and a common small 28-kDa regula...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Arthur, J. Simon C., Elce, John S., Hegadorn, Carol, Williams, Karen, Greer, Peter A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10825211/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.12.4474-4481.2000
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