The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-myc and Cyclin D1 in Transformation of Multiple Tissues

CDC37 encodes a 50-kDa protein that targets intrinsically unstable oncoprotein kinases including Cdk4, Raf-1, and v-src to the molecular chaperone Hsp90, an interaction that is thought to be important for the establishment of signaling pathways. CDC37 is required for proliferation in budding yeast a...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Stepanova, Lilia, Finegold, Milton, DeMayo, Franco, Schmidt, Emmett V., Harper, J. Wade
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10825210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.12.4462-4473.2000
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