The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-myc and Cyclin D1 in Transformation of Multiple Tissues

CDC37 encodes a 50-kDa protein that targets intrinsically unstable oncoprotein kinases including Cdk4, Raf-1, and v-src to the molecular chaperone Hsp90, an interaction that is thought to be important for the establishment of signaling pathways. CDC37 is required for proliferation in budding yeast a...

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Main Authors: Stepanova, Lilia, Finegold, Milton, DeMayo, Franco, Schmidt, Emmett V., Harper, J. Wade
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2000
נושאים:
Cell Growth and Development
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC85814/
https://ncbi.nlm.nih.gov/pubmed/10825210
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