Disruption of the 11-cis-Retinol Dehydrogenase Gene Leads to Accumulation of cis-Retinols and cis-Retinyl Esters

To elucidate the possible role of 11-cis-retinol dehydrogenase in the visual cycle and/or 9-cis-retinoic acid biosynthesis, we generated mice carrying a targeted disruption of the 11-cis-retinol dehydrogenase gene. Homozygous 11-cis-retinol dehydrogenase mutants developed normally, including their r...

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Hauptverfasser: Driessen, Carola A. G. G., Winkens, Huub J., Hoffmann, Kirstin, Kuhlmann, Leonoor D., Janssen, Bert P. M., Van Vugt, Anke H. M., Van Hooser, J. Preston, Wieringa, B. E., Deutman, August F., Palczewski, Krzysztof, Ruether, Klaus, Janssen, Jacques J. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85795/
https://ncbi.nlm.nih.gov/pubmed/10825191
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